MRI and PET in patients with locally advanced rectal cancer treated with preoperative radiochemotherapy.

Completed

Conditions: rectal cancer
rectal carcinoma
10017990
10017991

Registration Number: NL-OMON33842

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 15

Inclusion Criteria

Biopsy proven adenocarcinoma
Rectal tumor < 15 cm anal verge
T3-4N0-2M0: based on standard primary staging performed with MRI

Exclusion Criteria

Patients who meet exclusion criteria for MRI at 3T
Patients who meet exclusion criteria for Gadolinium intravenous contrast (kidney function GFR < 60ml/min/1.73m2 or nephrogenic systemic fibrosis)
Patients with insulin dependent diabetes mellitus or blood plasma glucose concentration higher than 10 mmol/L
Patients with inflammable bowel disease or diverticulitis
Patients with history of pelvic surgery
Patients with history of pelvic tumours

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Explorative study to determine the feasibility to apply anatomical and<br /><br>functional MRI and FDG-PET in the evaluation of treatment response after<br /><br>radiochemotherapy treatment for locally advanced rectal cancer compared to the<br /><br>pathological specimen as gold standard. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Determination of the most useful imaging variables and optimal timing sequence<br /><br>for the imaging modalities (diffusion weighted MRI, perfusion MRI and FDG-PET)<br /><br>to evaluate the tumour response on radiochemotherapy. </p><br>