Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate: A Double-blind Randomized Parallel Arm Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 79
- 试验地点
- 1
- 主要终点
- The consumption of dihydrocapsiate will significantly increase resting energy expenditure and fat oxidation
研究概览
简要总结
A 4 week intake of drug to find a natural substance that may modify energy balance and may enhance health in combination with lifestyle changes with possible decrease in body weight.
详细描述
This study is a double-blind, placebo-controlled, single center, randomized, parallel arm clinical trial to test the impact of Dihydrocapsiate (placebo, 3 and 9 mg/d) ingested for 4 weeks on resting metabolic rate and fat oxidation measured by indirect calorimetry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men between 20-60 years old
- •Healthy as assessed by medical history and standard medical exam
- •Weight-stable
- •Body mass index of 25 to 34.9 kg/m2
- •Non-smoker
- •Sedentary lifestyle: not being physically active grater than 3 days/week for 20 min each time for the previous 6 months, and not participating in regular resistance exercise.
排除标准
- •Subjects enrolled in a diet to increase or decrease body weight
- •Special diet or food aversiions to common foods
- •Has allergy to chilli pepper
- •Eating chilli peppers on a daily basis
- •Usually consuming more than 2 cups of tea or coffee/day
- •Usually consuming more than 4 cans of caffeinated soft drinks a day
- •Usually consuming more than 3 standard alcohol drinks/day
- •Regular use of medications (weight loss drugs, drugs affecting energy metabolism, drugs for depression)
- •Usual intake of illicit substances
- •Claustrophobia
- •Participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study
研究组 & 干预措施
Dihydrocapsiate
Drug 3 mg/d or 9 mg/d including Placebo
干预措施: Dihydrocapsiate (Other)
3 mg/d or 9 mg/d Dihydrocapsiate
Drug including Placebo
干预措施: Dihydrocapsiate (Other)
Sugar pill (Placebo o mg/d)
0 mg/d sugar pill
干预措施: Dihydrocapsiate (Other)
结局指标
主要结局
The consumption of dihydrocapsiate will significantly increase resting energy expenditure and fat oxidation
时间窗: 4 weeks
次要结局
未报告次要终点
研究者
Eric Ravussin
Principal Investigator
Pennington Biomedical Research Center