The Predictors for Continuous Renal Replacement Therapy in Liver Transplant Patient

Completed

• Conditions: Liver Transplantation

• Registration Number: NCT01457534
• Lead Sponsor: Yonsei University

Brief Summary

Background. Acute renal failure after liver transplantation (LT) requiring continuous renal replacement therapy (CRRT) adversely affects patient survival. However, there are few reports to assess the predictors for postoperative CRRT in liver transplant patients. The investigators undertook this study to identify perioperative factors that would predict patients at risk of CRRT.

Patients and Methods. The investigators retrospectively reviewed the data of 148 liver transplant patients from January 2007 to November 2010 at Severance Hospital, Yonsei University HealthSystem, in Seoul, Korea. The number of patients treated with CRRT was 44 (18 patients from living and 26 from deceased donors) and those without CRRT was 104. Univariate and stepwise logistic multivariate analyses were performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2011-02
• Study Completion: 2011-02
• Study First Submitted: 2011-10-04
• Study First Submitted QC: 2011-10-21
• Study First Posted: 2011-10-24
• Status Verified: 2013-02
• Last Update Submitted: 2013-02-26
• Last Update Posted: 2013-02-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

• Age 19-65 year
• Liver transplant patients from January 2008 to December 2011

Exclusion Criteria

• Patients treated with CRRT before transplantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
status before operation	1 day before operation	laboratory data(ex : total bilirubin, albumin, coagulation factors, blood gas analysis(arterial CO2 pressure. Blood urea nitrate/Creatinine, Hemoglobin/Hematocrit.)
the amount of ascites	intraoperative
the duration of anesthesia and operation	intraoperative
intraoperative hemodynamic instability	intraoperative
intraoperative bleeding	intraoperative
Intraoperative urine output	intraoperative
the types of donation(living or deceased donor)	intraoperative
survival rate	on the postoperative 28th days, 365 days
postoperative bleeding amount	on the postoperative 28th days, 365 days.
postoperative CRRT(continuous renal replacement therapy),	on the postoperative 28th days, 365days
mortality	on the postoperative 28th days, 365 days.

Trial Locations

Locations (1)

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of