Local Infiltration With Bupivacaine to Increase Quality of Post-operative Pain Control in Total Knee Replacement
Phase 4
Completed
- Conditions
- Pain, PostoperativeArthropathy of Knee Joint
- Interventions
- Drug: 0.9% normal saline
- Registration Number
- NCT01364194
- Lead Sponsor
- Mahidol University
- Brief Summary
The purpose of this study is to evaluate the efficacy of periarticular injection with 0.25% bupivacaine for controlling pain after total knee replacement to improve the quality of post-operative care.
- Detailed Description
Compare post operative pain control after total knee replacement by periarticular injection with 0.25% bupivacaine compare with 0.9% normal saline.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- primary osteoarthritis patients undergoing total knee replacement at Siriraj Hospital
- BMI between 20-35
- having a full understanding of the question in this trial
Exclusion Criteria
- allergy to NSAIDs, Acetaminophen, Bupivacaine
- blood creatinine more than 1.5 mg/dl or creatinine clearance less than 60 mL/min
- abnormal liver function
- previous surgery on the knee undergoing total knee replacement
- patient could not receive spinal anesthesia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 0.25% Bupivacaine 0.25% Bupivacaine Periarticular injection with 20 ml of 0.25% bupivacaine before wound closure. 0.9% normal saline 0.9% normal saline Periarticular injection with 20 ml of 0.9% normal saline before wound closure.
- Primary Outcome Measures
Name Time Method Post operative pain 96 hour post operation Measure by Visual analog scale scores and morphine consumption
- Secondary Outcome Measures
Name Time Method Complication of Morphine consumption 96 hour post operation nausea, pruritis, urinary retention and constipation
Trial Locations
- Locations (1)
Siriraj Hospital
🇹🇭Bangkoknoi, Bangkok, Thailand