Effects of Nonsurgical Periodontal Therapy on Plasma Hepatocyte Growth Factor Levels in Smokers and Non Smokers With Chronic Periodontitis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 40
- Primary Endpoint
- Primary outcome of the study was to measure plasma heaptocyte growth factor level
Study Overview
Brief Summary
This study is intended to measure hepatocyte growth factor levels in smokers and non smokers with periodontitis before and after non surgical periodontal therapy.
Detailed Description
The study was randomised prospective,interventional clinical trial. The sample size for the study was 40 individuals aged between 20 to 60 years,equally divided into two groups.
Group l - smokers with chronic periodontitis (test) group. Group ll - non smokers with chronic periodontitis (controls)
At baseline both the groups were analysed for clinical and biochemical parameters and underwent non surgical periodontal therapy( scaling and root planning). All parameters were reassesed after 3 months.
A total of 40 patients( 20 somkers and 20 non smokers) from the outpatient wing of department of periodontics, Panineeya mahavidyalaya institute of dental sciences and research centre diagnosed with chronic periodontitis and willing to participate in the study.
Clicical parameters included gingival index and periodontal index. Biochmeical parameters included plasma hepatocyte growth factor.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •probing depth >4mm
- •clinical attachment loss>2mm
Exclusion Criteria
- •patients younger than 20 years and greater than 60 years
- •presence of any chronic conditions like diabetes,infections
- •antibiotic therapy received preceeding 3 months
- •former smokers who had quit the habit of smoking
- •patients who already underwent periodontal therapy
Arms & Interventions
NSPT-Test group
NSPT was done after administration of pre procedural mouth rinse in the test group (20 smokers with chronic periodontitis).Clinical parameters (GI,PI) were assessed at baseline and at the end of 3 months.2 ml blood was drawn to asses the plasma hepatocyte growth factor levels at baseline and at the end of 3 months.
Intervention: NSPT (Other)
Scaling and root planing-Control group
Scaling and root planing was done after administration of pre procedural mouth rinse in the control group (20 non smokers with chronic periodontitis).Clinical parameters (GI,PI) were assessed at baseline and at the end of 3 months.2 ml blood was drawn to asses the plasma hepatocyte growth factor levels at baseline and at the end of 3 months.
Intervention: Scaling and root planing (Other)
Outcomes
Primary Outcomes
Primary outcome of the study was to measure plasma heaptocyte growth factor level
Time Frame: baseline, 3 months
The change in plasma hepatocyte growth factor level was measured at baseline and at the end of 3 months after scaling and root planing.2 ml blood was drawn from the patient to assess the hepatocyte growth factor levels.biochemical analysis was done by ELISA test i.e., blood samples from both smokers and non smokers with chronic periodontitis were taken at baseline and at the end of 3 monthd
Secondary Outcomes
- gingival index(baseline and 3 months)
- periodontal index(baseline and 3 months)
Investigators
C.BHARGAVI
PG STUDENT
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre