Effect of Rapid Transfusion With Fluid Management System (FMS) on Plasma Potassium in Liver Transplantation Recipients

Completed

• Conditions: Condition Requiring Rapid Transfusion During Liver Transplantation Surgery

• Registration Number: NCT01331889
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Rapid infusion of red blood cells is known to result in hyperkalemia in the body. However, potassium concentration in the blood mixture (usually made of RBC, FFP and normal saline) in the reservoir of rapid infusion system and its effect on the plasma potassium change during rapid transfusion are unknown. This study is designed to investigate these changes while massive transfusion is performed during liver transplantation surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-04-05
• Study First Submitted QC: 2011-04-07
• Study First Posted: 2011-04-08
• Study Start: 2011-10
• Primary Completion: 2015-03
• Study Completion: 2016-04
• Status Verified: 2016-07
• Last Update Submitted: 2016-07-06
• Last Update Posted: 2016-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• preoperative anemia (hemoglobin < 10 g/dl)
• preoperative coagulopathy

Exclusion Criteria

• children under age 18
• low risk of intraoperative bleeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
potassium concentration in the Fluid Management System (FMS) reservoir	after transfusion of 150 ml of blood mixture	During bolus transfusion (300ml) of blood mixture, blood sample is taken from the side port of infusion line of Fluid Management System (FMS) when 150 ml of blood mixture was transfused. Because the priming volume of the internal circuit is approximately 100 ml, blood sample that was taken after 150 ml transfusion represents the content in the reservoir.

Secondary Outcome Measures

Name	Time	Method
plasma potassium of the patient	before and after transfuison of 300 ml of blood mixture	Just before transfusion starts, blood samples are taken from the central venous catheter and arterial line at the same time to measure baseline values. At the immediate end of transfusion, blood samples are taken again from the same sites to measure the resultant changes.

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of