Effect of high frequency transcranial magnetic stimulation on negative symptoms and cognitive functioning in schizophrenia: a combined treatment and neuroimaging study

Phase 2

Completed

• Conditions: distortion of reality; mental disorder; 10039628

• Registration Number: NL-OMON37140
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

Patients included must have prominent negative symptoms and patients must have a negative subscore >= 15 on the Positive and Negative Syndrome Scale for Schizophrenia (PANSS). Only patients who are fully capable of making their own decision regarding participation in the research will be included.

Exclusion Criteria

Exclusion criteria include rTMS and MRI contraindications (e.g. a personal or family history of epileptic seizures, history of brain surgery, intracerebral or pacemaker implants, inner ear prosthesis or other metal prosthetics/implants), neurological disorders, a head injury with loss of consciousness in the past, substance dependency within the previous 6 months, previous treatment with rTMS, severe behavioural disorders, inability to provide informed consent and claustrophobia. Female patients who are pregnant will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified