Early P Gingivalis Oral Infection and Ultrasound Detection of Intimamedia Thickening in Radial Arteries of Young Children
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Arterial wall thickness
研究概览
简要总结
To determine if there is an association between Porphyromonas gingivalis infection of dental gingiva during primary tooth eruption and thickening of the radial artery intimamedial layers. Thickening of these layers in infants could be a promoting factor for later development of atherosclerosis.
详细描述
Specific Aim 1. To determine the presence of Pg in the mouth of edentulous pre-eruption and then teething infants.
Over a 9-month period 15 normal babies will be recruited for a prospective pilot study from Creighton University students. Cotton swabs of the tongue mucosa and dental plaque will be made to detect the presence of Pg by DNA analysis.
Specific Aim 2. To determine the daily temperature of infants. Daily child temperatures will be recorded by the parent. Specific Aim 3. To measure the thickness of the radial artery using a 50 MHz ultrasound probe.
A 50 MHz ultrasound scan will be made by a trained dental hygienist of the left radial artery at an initial visit and at 3-monthly intervals to measure IMT.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Months 至 24 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Pre-primary tooth eruption infants in the range of 4-8 months -
排除标准
- •No erupted teeth. No diabetes, obesity, chronic inflammatory disorders, hyperlipidemia, -
结局指标
主要结局
Arterial wall thickness
时间窗: 9 months
Increase in thickness of intimamedia layers
次要结局
未报告次要终点
研究者
Douglas K Benn DDS, PhD
Professor
Creighton University