Effect of low flow and minimal flow Desflurane anaesthesia on inspired oxygen concentration in obese patients undergoing elective surgery under general anaesthesia: A Randomised parallel group study
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Change in inspired oxygen concentration in low flow and minimal flow desflurane anaesthesia.
研究概览
简要总结
Any technique that employs Fresh Gas Flow that is less than alveolar ventilation can be designated as low flow anaesthesia.Here the fresh gas flow is kept to a maximum of 1 lpm.The principle is to replenish the consumed gas with as minimal fresh gas as possible thereby making it physiologically, economically beneficial and sustainable. Minimal flow anaesthesia is subtype of low flow anaesthesia with maximum FGF of 0.5 lpm.One of the potential risks associated with low flow anaesthesia is risk of hypoxia.During low flow anaesthesia, as the flow rate is decreased, the gradient between oxygen content of blood and inspired oxygen concentration of gas mixture increases.With increase in metabolic demands, the oxygen consumption may exceed the total delivered oxygen and lead to hypoxic mixture to the patient.
There are few studies that have compared the change in delivered gas consumption during minimal flow and low flow anesthesia technique with desflurane in obese population.Hence , we wish to study the effect of low flow and minimal flow desflurane anaesthesia on inspired oxygen concentration in obese patients with desflurane undergoing elective surgery under general anaesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1 ASA Physical status of I and II.
- •2.Duration of Low flow or minimum flow anaesthesia of at least 90 minutes.
排除标准
- •Patients with known history of hepatic, renal or cardiovascular disease.
- •Patients with preoperative pulmonary dysfunction, acute or chronic lung disease.
- •3.Pregnancy.
结局指标
主要结局
Change in inspired oxygen concentration in low flow and minimal flow desflurane anaesthesia.
时间窗: After 10 minutes of Low flow anaesthesia for every 15 minutes interval till the end of surgery/ 180 minutes
次要结局
- Total oxygen consumed per hour in low flow and minimal flow anaesthesia.
- Total Desflurane consumed per hour in low flow and minimal flow anaesthesia.
研究者
Dr Sherigar Mahesha Ravi
Maulana azad medical college