The influence of the proteins of the contact activation system on thrombus formation under different flow-conditions in blood

Recruiting

• Conditions: arterial thrombosis; increased coagulation; 10064477; 10014523

• Registration Number: NL-OMON39076
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 46

Inclusion Criteria

• Age: >= 18 years
• Deficiency in coagulation factor XII, coagulation factor XI, prekallikrein or high molecular weight kininogen (patients)

Exclusion Criteria

(Other) Coagulation defects
Symptoms of active disease
Use of anti-platelet drugs
Use of aspirin / ascal

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our main study endpoint is the ex vivo formation of thrombi in several<br /><br>coagulation assays. We hypothesize that thrombi formed from blood of patients<br /><br>deficient in FXII or FXI are less stable than those formed from blood from<br /><br>controls. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>