Comparison of blood transfusion in patient received tranexamic acid in femoral shaft fracture who operated with plate and screw fixation, randomized control trial.
Phase 2
Recruiting
- Conditions
- Perioperative bleeding in femoral shaft fracture patient, operated with plate and screw fixation.tranexamic acid, femoral shaft fracture, femur fracture, ORIF, plate and screw, blood transfusion
- Registration Number
- TCTR20220701003
- Lead Sponsor
- Khon Kaen Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 102
Inclusion Criteria
1.Age > 18 years old 2.Unilateral Femoral shaft fracture (AO classification type A,B) 3.Operated with ORIF with plate and screw
Exclusion Criteria
1.Associated with hemothorax, intra-abdominal bleeding or pelvic fracture
2.Receive more than one operation during admission
3.Contraindicated in tranexamic acid: TXA allergy, acquired defective color vision ,subarachnoid hemorrhage, history of venous or arterial occlusion disease
4.Pregnancy
5.Underlying disease with dependent transfusion
6.Currently using antifibrinolytic or anticoagulant medications
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method unit of packed red cell transfusion until discharge unit
- Secondary Outcome Measures
Name Time Method Hemoglobin level post op 24 h until discharge g/dL,adverse event of tranexamic acid (Deep vein thrombosis, Pulmonary Embolism, allergy) until discharge event