Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- TGF beta-1 levels
研究概览
简要总结
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus
详细描述
The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12
The specific aims of this research proposal are to:
- Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement.
- Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Normal Pressure Hydrocephalus
排除标准
- •Patients not diagnosed with Normal Pressure Hydrocephalus
结局指标
主要结局
TGF beta-1 levels
时间窗: Time of Surgery
Mini-mental status exam
时间窗: Pre-operative, 3 and 12 months post-operatively
Modified barthel index
时间窗: Pre-operative, 3 and 12 months post-operatively
Tinetti mobility assessment
时间窗: Pre-operative, 3 and 12 months post-operatively
次要结局
- Programmable shunt setting(Pre-operative, 3 and 12 months post-operatively)