The Effectiveness of Continuous Ketamine Infusion (KONTINUE)

Completed

• Conditions: Chronic Pain

• Registration Number: NCT06131970
• Lead Sponsor: Centre Hospitalier Princesse Grace

Brief Summary

There are different treatment for chronic pain. One possible treatment is intravenous infusions of ketamine.

Detailed Description

Ketamine continuous intravenous infusion for 4 days in Hospital with 0.5 mg/kg/day associated with Magnesium Sulfate 1000mg/day.

Evaluation schedules will be performed at day 15,30 and 60.

Study Timeline

• Study Start: 2022-02-22
• Study First Submitted: 2023-11-07
• Study First Submitted QC: 2023-11-13
• Study First Posted: 2023-11-15
• Primary Completion: 2024-08-06
• Study Completion: 2024-08-06
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-17
• Last Update Posted: 2025-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Pain lasting for more than six months without contraindication to treatment

Exclusion Criteria

• Inability to give consent
• Severe psychiatric disorder

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Long-term effectiveness	1 month	Clinical Global Impression of Change (CGI-C) - score 1 to 7 - 7 is the worst

Secondary Outcome Measures

Name	Time	Method
Pain relief	15, 30, 60 days	Neuropathic Pain Symptom Inventory (NPSI) - score 0 to 10 - 10 is the worst
Variation of quality of life	15, 30, 60 days	Hospital Anxiety and Depression scale - score 0 to 21 - 21 is the worst

Trial Locations

Locations (1)

Centre Hospitalier Princesse Grace; 🇲🇨 Monaco, Monaco