Healthy Longevity and Mortality in Long-living Adults: Contributors and Causes - Lifestyle, Socioeconomic Background, and Replicative Aging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- LONGEVITY 1
- Sponsor
- Center for Strategic Planning, of the Federal Medical and Biological Agency
- Enrollment
- 4000
- Locations
- 1
- Primary Endpoint
- Mortality among long-living adults
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.
The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity.
The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.
Detailed Description
The study involves a long-term observation of a cohort of long-living adults. During the first visit, a medical professional will take a detailed medical history and perform a comprehensive geriatric assessment (for 15 geriatric syndromes), and physical examination. The participants will have their biomaterials sampled for basic and extended blood biochemistry testing, telomere length measurement, common urine tests and subsequent biobanking and additional studies: whole genome sequencing, DNA methylation analysis, transcriptome analysis, and 16S RNA sequencing of stool and saliva. Follow-up checks will be carried out once a year by phone or during additional visits. The study seeks to identify the genetic, epigenetic, and metagenomic determinants associated with the successful and unsuccessful aging phenotypes, mortality, and survival in long-living individuals.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Informed consent
- •90 years of age or above
Exclusion Criteria
- •Refusal to participate or to provide informed consent;
- •Any other criteria deemed reasons for exclusion by the Principal Investigator.
Outcomes
Primary Outcomes
Mortality among long-living adults
Time Frame: at least 1 year after inclusion in the study
Mortality among long-living adults within at least 1 year after inclusion in the study and factors associated with mortality will be assessed.
Morbidity among long-living adults
Time Frame: at least 1 year after inclusion in the study
Morbidity among long-living adults within at least 1 year after inclusion in the study and factors associated with morbidity will be assessed.
Secondary Outcomes
- Social, economic, and medical- history-related determinants(at least 2 years after inclusion in the study)
- Metagenomic determinants(at least 2 years after inclusion in the study)
- Aging phenotypes(at least 2 years after inclusion in the study)
- Epigenetic determinants(at least 2 years after inclusion in the study)
- Genetic determinants(at least 2 years after inclusion in the study)