Is skeletal muscle microvascular dysfunction a key determinant of exercise intolerance and impaired glycaemic control in patients with type 2 diabetes?

Deakin University0 个研究点目标入组 56 人开始时间: 2020年2月26日最近更新: 2023年2月27日

适应症

试验速览

暂无简介。

•1.Aged 40–80 years.
•2.Clinical diagnosis of pre-diabetes (HbA1C = 5.7%) or T2D (HbA1C = 6.5%)
•Controlled diabetes through diet or medication (excluding insulin) for at least 8 weeks.
•3.Have given signed informed consent to participate in the study.

•1.Age <40 years or > 80 years.
•2.Patients using insulin to control blood sugar levels.
•3.Pulmonary hypertension.
•4.Atrial fibrillation.
•5.Cardiovascular disease including coronary artery disease or heart valve disease.
•6.Poor ejection fraction (<50%) or elevated left ventricle filling pressure (E/e’ >15).
•7.Critical limb ischemia including peripheral artery disease or previous revascularisation or other surgical treatment for peripheral artery disease.
•8.History of malignancy within past 5 years (except for non-melanoma skin cancers).
•9.Identification of any medical condition requiring immediate therapeutic intervention.
•10.Uncontrolled hypertension (resting brachial blood pressure greater than or equal to 160/100 mmHg).
•11.Other non-cardiovascular barriers to exercise
•12.Current or previous smoker with past 12 months.
•13.Participation or intention to participate in a structured and/or supervised physical activity program during the study period.
•14.History of severe liver disease.
•15.Elective major surgery during the course of the study.
•16.Pregnancy/lactation.

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