Paediatric Ards Neuromuscular Blockade Study
- Conditions
- ARDS
- Interventions
- Drug: Neuromuscular Blocking AgentsDrug: Isotonic saline
- Registration Number
- NCT02902055
- Lead Sponsor
- University Medical Center Groningen
- Brief Summary
Paediatric acute respiratory distress syndrome (ARDS) is a manifestation of severe, life-threatening lung injury. Care for paediatric patient is mainly supportive and based on what works in adults and personal experiences, including the use of mechanical ventilation. However, differences in lung physiology and immunology between (young) children and adults suggests that adaptation of adult practices into paediatrics may not be justified. A study in adults with severe ARDS showed that early use of neuromuscular blocking agents (NMBA) improved 90-day survival and increased time off the ventilator without increasing muscle weakness. It is unknown if this is also true for paediatric ARDS
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 3
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Rocuronium 1 mg/kg i.v. Neuromuscular Blocking Agents Neuromuscular blocking agent Isotonic saline Isotonic saline -
- Primary Outcome Measures
Name Time Method the cumulative respiratory morbidity score 12 months after PICU discharge, adjusted for confounding by age, gestational age, family history of asthma and/or allergy, season in which questionnaire was filled out and parental smoking 12 months after PICU discharge
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UMC Groningen
🇳🇱Groningen, Netherlands