A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery

Phase 4

• Conditions: Coronary Artery Bypass Surgery
• Interventions: Drug: Ketamine; Drug: Etomidate

• Registration Number: NCT01386229
• Lead Sponsor: Baskent University

Brief Summary

The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03
• Status Verified: 2011-06
• Study First Submitted: 2011-06-21
• Study First Submitted QC: 2011-06-30
• Last Update Submitted: 2011-06-30
• Study First Posted: 2011-07-01
• Last Update Posted: 2011-07-01
• Primary Completion: 2011-12
• Study Completion: 2012-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass
• Patient's written informed consent for study participation
• Ejection fraction ≥ 35%

Exclusion Criteria

• Allergy to study drugs
• Redo surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ketamine	Ketamine	-
Etomidate	Etomidate	-

Primary Outcome Measures

Name	Time	Method
A more than 15% change in mean arterial pressure and heart rate after anesthesia induction	For 60 minutes after anesthesia induction

Secondary Outcome Measures

Name	Time	Method
Adrenal gland steroid synthesis suppression	24 hours and 5 days after study drug administration	A less than 9 microgram/dl increase in serum cortisol after stimulation with adrenocorticotropic hormone

Trial Locations

Locations (1)

Baskent University, Faculty of Medicine; 🇹🇷 Ankara, Çankaya, Turkey