Correlate the atherogenic indices with cardiovascular risk in psoriasis patients:A cross-sectional study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- To correlate the atherogenic indices with cardiovascular risk in psoriasis patients
研究概览
简要总结
Patient will be enrolled in the department of dermatology . History taking will be done including onset, duration and course of the disease. Clinical Examination will be done to detect association (nail changes and any other autoimmune disease) and to determine the extent of Psoriasis Vulgaris, which will be assessed using the Psoriasis Area and Severity Index (PASI) Score.
Anthropometric examination including Height, Weight, Body Mass Index(BMI), Waist circumference, Hip circumference, waist to hip ratio, will be done and baseline laboratory examinations including LFT, RFT, RBS and lipid profile consisting of cholesterol, low density lipoprotein(LDL), high density lipoprotein (HDL),Triglyceride and VLDL will be included. Blood samples will be collected after overnight fasting for analysis using (mention analyser used in biochem department)
Atherogenic Indices including Atherogenic Index of Plasma (AIP), Castelli Risk Index I and II (CRI), Atherogenic Coefficient (AC), and non-high density lipoprotein cholesterol (HDLc) (NHC)will be used to assess the risk of cardiovascular disease. These indices are calculated as:
·AIP = Log (serum triglyceride/serum HDLc).
·CRI-I = Serum total cholesterol/Serum HDLc.
·CRI-II = Serum low-density lipoprotein (LDL)cholesterol/Serum HDLc
·AC=(Serum total cholesterol-Serum HDLc)/HDLc.
·NHC=(Serum total cholesterol-Serum HDLc)
CIMT: Double-check the CIMT values on both sides to achieve reproducibility, the mean values will be generated for CIMT. The American Institute of Ultrasound in Medicine’s (AIUM) standards will serve as the foundation for the common carotid artery (CCA) sonographic protocol.
Patient’s Proforma (Annexure-I) will be filled for all the patients included in the study.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients above 18 years of age 2.Patients of psoriasis who have not taken any form of treatment in the last 1 month.
- •3.Patients who are willing to sign the written consent form before participating in the study.
排除标准
- •1.Patient having history of chronic hepatic and renal disease, diabetes mellitus, cardiovascular diseases and malignancies.
- •2.Those with history of chronic smoking, drug abuse and having morbid obesity (BMI above 30kg/square metre).
- •3.Patients who are taking lipid-lowering agents.
- •4.Patients having chronic inflammatory disease, immunological disorders with associated endothelial dysfunction.
- •5.Pregnant and lactating female.
结局指标
主要结局
To correlate the atherogenic indices with cardiovascular risk in psoriasis patients
时间窗: Outcome will be assessed at the time of patient visit
次要结局
- To study any correlation between Atherogenic Indices & CIMT with disease severity
研究者
Shahrukh Alam
All India Institute of Medical Sciences