Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm
Not yet recruiting
- Conditions
- Intracranial Sacciform Aneurysm
- Interventions
- Biological: analysis of foecal microbiota
- Registration Number
- NCT05914636
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation. The objective of this study is to describe microbiota with taxonomic and metabolomic analysis. A comparison between ruptured and unruptured intracranial aneurysm will be performed. The study hypothesis is that microbiota is different between ruptured and unruptured patient.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- one or more intracranial sacciform aneurysm ruptured or not in function of the inclusion group
Exclusion Criteria
- Transient modification of microbiota: Antibiotherapy in the last 3 months, pre or probiotic in the last month, gastrostomy, ileostomy, bariatric surgery, digestive tract resection, gastro-duodenal ulcer surgery or during the last month, chronic inflammatory disease of the digestive tract (like Crohn), BMI for more than 30, Very restrictive diet (like vegan
- Specific pathologies increasing the incidence of aneurysm ( kidney autosomic dominant polycystosis, Type 1 neurofibromatosis, Rendu-Osler, MArfan
- Participation to a study with the objective of microbiota modification
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description unruptured analysis of foecal microbiota Patient with an unruptured intracranial sacciform aneurysm for all location. The diagnosis of unuptured aneurysm is made on MRI, Angio-CT or digital substraction angiography with no doubt Ruptured analysis of foecal microbiota Patient with a ruptured intracranial sacciform aneurysm for all location. The diagnosis of ruptured aneurysm is made on MRI, Angio-CT or digital substraction angiography with no doubt
- Primary Outcome Measures
Name Time Method Taxonomic faecal microbiota description The faecal samples will be taken at 3 days+/-2 after the ruptured and during the arteriography for the unruptured group within 3 months after inclusion The results of the taxonomic analysis of fecal samples will be described in the two groups. Interesting parameter will be selected for further analysis
- Secondary Outcome Measures
Name Time Method