Influence of the intestinal microbiome on the risk of spontaneous bacterial peritonitis in patients with decompensated liver cirrhosis
Suspended
- Conditions
- K65K74.6PeritonitisOther and unspecified cirrhosis of liver
- Registration Number
- DRKS00026834
- Lead Sponsor
- Klinik und Poliklinik für Innere Medizin II Klinikum rechts der Isar der TU München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Suspended
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
patients with liver cirrhosis (confirmed by ultrasound, CT or histology) and ascites
- indication for paracentesis
Exclusion Criteria
- age <18 years
- unable to give informed consent
- pregnancy
- SBP at admission
- antibiosis within 14 days prior to recruitment
- status post liver transplantation
- pharmacological or acquired (e.g. HIV) immune deficiency
- surgery within 6 months prior to recruitment
- status post colectomy
- active neoplastic disease
- secondary peritonitis
- patients on ICU
- cirrhose cardiac
- cleansing for colonoscopy
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Analysis of the gastrointestinal microbiome in patients with SBP: <br>• Description of the microbiome in those patients in specimen of the oral cavity, the duodenum, the ascites and the stool<br>• Comparison of the microbiome of patients with and without SBP
- Secondary Outcome Measures
Name Time Method 2) Analysis of oral overgrowth of the microbiome in the small intestine by typical oral bacteria by comparison of duodenal and faecal with oral (saliva) samples. <br>3) Changes in the microbiome as risk factor of SBP.<br>• Multivariate regression analysis of SBP risk factors<br>• Association of pathogens in ascites / ascitic microbiome with changes in the intestinal microbiome