To Study the Impact of Frailty on Postoperative Complications in Oncosurgeries
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Frailty
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- To study incidence of postoperative complications in frail patients
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Advanced ageing is accompanied by loss of reserve in multiple organ systems leading to increased risk of complications after surgery.Frailty is a functional syndrome involving reduced physiological reserve and 25-56% of all elderly surgical patients are reported to be frail .
Detailed Description
Patients above 65 years age undergoing major Oncosurgery under general anaesthesia with or without Epidural will included , written informed consent will be obtained from all patients. Age, Heigth , Weigth , polypharmacy , smoking status , history of Diabetes ,Hypertension will be noted. Basic investigation Hb% , Serum Albumin , Serum creatinine will be done. ASA Physical status and Surgical risk will be noted .Patients will be evaluated for Frieds 5 point Frailty Assessment Scale (i) Unintended weigth loss of \> 5kg in last one year.(ii) self reported exhaustion, (iii) muscle weakness (grip strength) (iv)slow walking speed,(v) Low physical activity and assigned to either No Frail Group (0 criteria) , Pre-Frail (1-2 positive criteria ), Frail (3-5 positive criteria Group).The assessment will be done in the preoperative anaesthesia clinic and include paper based questionnaire, hand dynamometer to measure muscle strength and walking test . All patients will receive standard general anaesthesia along with Epidural for Abdomino-pelvic surgeries.Intraoperative monitoring 5 lead ECG, NIBP/IBP , SPO2, ETCO2, CVP(Optional),BIS will be done.After induction of anaesthesia Ultrasonography will be performed with curvilinear probe --- at the midpoint of femur anteriorly to measure Rectus Femoris muscle thickness of Right thigh , three consecutive readings will be measured and average of value noted for all patients. At the end of surgery patient's neuromuscular block will be reversed and trachea extubated , if any patient requires ventilator support note will be made accordingly. Postoperative patients vitals and Input/Output charting will be done .Postoperative analgesia either epidural analgesia or intravenous opioids according to Institutional protocol will be given .Length of ICU Stay and any major cardiac , respiratory , Renal complications , re-exploration will be noted.
Investigators
Dr Anita Kulkarni
Principal investigator
Rajiv Gandhi Cancer Institute & Research Center, India
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing major onco-surgey
Exclusion Criteria
- •Patient refusal to participate
- •Age \<65 years.
- •Emergency surgery
- •Pre-existing dementia
- •Language barrier
Outcomes
Primary Outcomes
To study incidence of postoperative complications in frail patients
Time Frame: upto 7 days
Postoperative major complications as myocardial infarction, Respiratory failure, cerebrovascular event, renal failure , re-exploration will be noted and statistically analysed.
Secondary Outcomes
- Length of ICU stay(upto 240 hours.)