Focused fMRI and Brainstem Evoked Response Audiometry (BERA) to Probe the Brainstem Mechanism in Tinnitus
- Conditions
- Ringing in the ears10027667
- Registration Number
- NL-OMON48145
- Lead Sponsor
- Keel-, Neus- en Oorheelkunde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
To be eligible to participate in this study, the subject
- must be in the age range of 18-80 years old.
- must have a hearing threshold of both ears between 40 dB and 60 dB, if he/she
is in one of the bilateral hearing loss groups.
- must have a hearing threshold between 40 dB and 60 dB for one ear, and the
normal hearing threshold, less than 20 dB, for the other ear, if he/she is in
one of the unilateral hearing loss groups.
- must have a hearing threshold of less than 20 dB for both ears, if he/she is
in one of the normal threshold groups.
- Non-conformance to any of the inclusion criteria.
- Contraindication for MRI according to the MRI checklist.
- Reported medical, neurological, or psychiatric disorders (excluding tinnitus
and hearing loss).
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoints are differences between response characteristics associated<br /><br>with hearing loss laterality and the presence of tinnitus. These differences<br /><br>include the difference in the response amplitudes of various brainstem nuclei<br /><br>as assessed by fMRI, BERA and, tonotopic maps as assessed by MRI.</p><br>
- Secondary Outcome Measures
Name Time Method <p>n.v.t</p><br>