Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa

Completed

• Conditions: Bulimia Nervosa

• Registration Number: NCT02997475
• Lead Sponsor: University of California, San Diego

Brief Summary

The purpose of this study is to investigate areas of the brain responsible for self-regulation in adult women who have never had an eating disorder with women who have bulimia nervosa. More specifically, investigators are interested in changes in brain activation (e.g., changes in blood flow and oxygen use) when inhibiting responses and regulating emotions. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-10-25
• Study First Submitted QC: 2016-12-15
• Study First Posted: 2016-12-20
• Primary Completion: 2022-07-31
• Study Completion: 2022-07-31
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-13
• Last Update Posted: 2023-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 89

Inclusion Criteria

• Female

• Right-handed

• Between the ages of 18 and 35 years

  *For Women with Bulimia Nervosa:

• Binge eating (i.e., eating a large amount of food while experiencing a sense of loss of control)

• Purging via self-induced vomiting (other methods may also be endorsed)

General

Exclusion Criteria

• Current significant medical illness or condition (e.g., diabetes, thyroid disease)
• Pregnancy, planned pregnancy, or lactation during the study period
• Non-removable metallic objects in the body

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Self-Regulatory Control	Day 2 (fMRI Scan)	Functional Magnetic Resonance Imaging will be used to assess brain activation associated with motor inhibitory control and affect regulation in women with bulimia nervosa (BN)

Secondary Outcome Measures

Name	Time	Method
Eating Disorder Relevance	Day 0	The Eating Disorder Examination (EDE) will be conducted to assess relative associations of motor, affective, and goal-directed action control with bulimia nervosa severity.
Goal-Directed Action Control	Day 1	An computerized instrumental learning task will be used to assess performance of women with and without bulimia nervosa.

Trial Locations

Locations (1)

UCSD Eating Disorders Center for Treatment and Research; 🇺🇸 San Diego, California, United States