An fMRI Study of Self-regulation in Adolescents With Bulimia Nervosa
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Eating Disorders
- Sponsor
- New York State Psychiatric Institute
- Enrollment
- 71
- Locations
- 1
- Primary Endpoint
- Magnetic Resonance Imaging Scans
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim of this project is to use both multimodal MRI and behavioral measures to investigate how changes in frontostriatal neural systems contribute to the development and persistence of Bulimia Nervosa (BN). Findings from this study will have wide-ranging importance for our understanding of the development and treatment of BN.
Detailed Description
Patients with Bulimia Nervosa (BN) have difficulty regulating impulsive behaviors as suggested by their binge-eating and purging, as well as the high incidence of drug abuse and shoplifting in this population. Understanding dysfunction in the frontostriatal circuitry that mediates self-regulatory control processes will aid development of new therapeutics for the impulsivity associated with BN. We are conducting a longitudinal study to better understand the development and persistence of BN. Participation in this study includes 4 sections: Neuropsychological Tests, Diagnostic interviews, Pregnancy Test, and MRI scan. All efforts are made to coordinate procedures into one day, and they require between 4 and 5 hours of the participant's time. The option of splitting participation into two study days is also offered for participants who find it more convenient. Participants are compensated with $100 in the form of a check, which is mailed to their home address. Participants will be invited back for follow-up visits.
Investigators
Rachel Marsh
Research Scientist
New York State Psychiatric Institute
Eligibility Criteria
Inclusion Criteria
- •Current or prior DSM IV diagnosis of Bulimia Nervosa or Sub-threshold Bulimia Nervosa (those who meet all DSM-IV criteria for BN, but engage in subjective binge-eating episodes and binge/purge at a frequency of at least once per week for 3 months, whereas meeting full DSM-IV criteria for BN requires binge eating and purging twice per week for 3 months)
- •Major Depression
- •For control adolescents, no current or past history of an eating disorder
Exclusion Criteria
- •Ferromagnetic implants (e.g., pacemaker)
- •Metal braces or retainers
- •IQ less than 80
- •Any other current major Axis I disorder, other than major depressive disorder (MDD)
- •History of concussion, seizure disorder, or other neurological illness
- •Claustrophobia
Outcomes
Primary Outcomes
Magnetic Resonance Imaging Scans
Time Frame: Baseline
This study will use magnetic resonance imaging (MRI) to assess the structure (cortical thickness) of neural circuit regions involved in Bulimia Nervosa (BN).
Secondary Outcomes
- Weather Prediction Task(Baseline)
- Stroop Word-Color Interference(Baseline)
- Conners Continuous Performance Test-II (CPT-II)(Baseline)