Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study

Completed

• Conditions: Bipolar Disorder; Major Depression; Rumination
• Interventions: Other: Functional Magnetic Resonance Imaging (fMRI)

• Registration Number: NCT02253225
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

The investigators propose to examine both resting state activity and functional activity during rumination and during self-processing to study the relationship between neural correlates of rumination/self-focus and self-processing in major depression and bipolar disorder.

Detailed Description

Negative rumination, a specific form of self-focus, characterized by repetitively focusing on one's symptoms of distress, and the possible causes and consequences of these symptoms, is a hallmark of depression. Nearly a decade of research has culminated in evidence that the tendency to engage in negative rumination is highly correlated with depressive symptoms. Rumination also plays a critical role in the etiology and maintenance of depressed states and predicts risk for mania in bipolar disorder. Despite the central role of rumination in major depression and bipolar disorder, there have been few studies to date investigating the functional neuroanatomy of negative rumination, and no studies of positive rumination. The few neuroimaging studies that have utilized measures of the tendency to engage in negative rumination have focused on brain functioning when performing tasks that involve processing emotional or self-referential stimuli, but they have not studied resting state activity or functional activity during negative and positive rumination. We are examining both resting state activity and functional activity during negative and positive rumination and during self-processing to study the relationship between the neural correlates of rumination/self-focus and self-processing in major depression and bipolar disorder.

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2014-09-24
• Study First Submitted QC: 2014-09-26
• Study First Posted: 2014-10-01
• Primary Completion: 2020-01
• Study Completion: 2020-01
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-31
• Last Update Posted: 2021-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy Control	Functional Magnetic Resonance Imaging (fMRI)	Clinical status will be determined using the Mini International Neuropsychiatric Interview (M.I.N.I) for 20 normal, healthy volunteers.
Bipolar Disorder	Functional Magnetic Resonance Imaging (fMRI)	Clinical status will be determined using the Mini International Neuropsychiatric Interview (M.I.N.I) for 20 patients with bipolar disorder (BPAD).
Major Depressive Disorder	Functional Magnetic Resonance Imaging (fMRI)	Clinical status will be determined using the Mini International Neuropsychiatric Interview (M.I.N.I) for 20 patients with major depression (MDD).

Primary Outcome Measures

Name	Time	Method
Functional Magnetic Resonance Imaging (fMRI) to examine self processing and self focus	Participants will be analyzed as quickly as possible after a screening visit, an expected average of 2 weeks	Functional Magnetic Resonance Imaging (fMRI) will be used to look at the neuroanatomy of self processing and self focus.

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States