The Burden of COVID-19 Survivorship: Exercise Therapy to Combat the Sequelae of COVID-19
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- Mayo Clinic
- Enrollment
- 27
- Locations
- 1
- Primary Endpoint
- Maximal oxygen update (VO2max) measured in mL/kg/min
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This research study is being done to find out what the longer-term physiological consequences of COVID-19 are, and to determine if exercise therapy can help improve lung function, heart function and overall fitness, and reduce symptoms in people recovering from SARS-CoV-2.
Detailed Description
The purpose of this research is to see if taking part in structured exercise training will improve the ability to exercise, the function of the lungs and the function of the heart, and reduce symptoms of fatigue and breathlessness in people recovering from COVID-19. After enrollment all patients will complete exercise testing, lung function testing, and cardiac imaging. Patients will be randomized to either 8 weeks of exercise training (4-5 times per week) or will continue standard medical care. All patients will undergo detailed exercise testing, lung function testing, and cardiac imaging after the intervention.
Investigators
Bryan Taylor
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Aged 21 to 75 years.
- •History of RT-PCR proven SARS-CoV-2 infection.
- •Deemed 'recovered' from SARS-CoV-2 infection.
- •Not clinically obese (BMI ≥ 36) and/or suffer from musculoskeletal or other conditions that would limit exercise participation.
- •No evidence of cardiac ischemia at rest or during exertion (via ECG).
- •Able to provide written informed consent.
Exclusion Criteria
- •Individuals less than 21 or more than 75 years old.
- •Not able to take part in structured exercise training due to injury or other conditions that would put person at risk during exercise.
- •Unable to provide written informed consent.
Outcomes
Primary Outcomes
Maximal oxygen update (VO2max) measured in mL/kg/min
Time Frame: 8 weeks
VO2max is the maximal oxygen consumed during an exhaustive exercise test
Secondary Outcomes
- Right ventricular contractile function measured as % fractional area change (RV FAC)(8 weeks)
- Forced vital capacity (FVC) measured in L(8 weeks)
- Forced expiratory volume in 1 second (FEV1) measured in L(8 weeks)
- Maximal inspiratory pressure (MIP) measured in cmH2O(8 weeks)
- Peak exercise work rate (Wpeak) measured in Watts(8 weeks)
- Left ventricular contractile function measured as % fractional area change (LV FAC)(8 weeks)
- Maximal expiratory pressure (MEP) measured in cmH2O(8 weeks)