Effectiveness of Neostigmine as reversal agent in patients undergoing general anesthesia with Cis-atracurium
Phase 3
- Conditions
- Health Condition 1: Z00-Z99- Factors influencing health status and contact with health services
- Registration Number
- CTRI/2024/05/067410
- Lead Sponsor
- Dr Deepshikha Patangia
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients aged 20 to 60 years
2.American Society of Anesthesiology (ASA) physical status I and II
3.Scheduled for elective surgery under general anesthesia
4.Duration of surgery less than 3 hours.
Exclusion Criteria
1.Patients with a BMI = 25 kg/m2
2.Pregnant or lactating women
3.With significant hepatic or renal dysfunction
4.With respiratory pathologies like COPD or is a chronic smoker
5.Family history of malignant hyperthermia
6.Any known allergy to one of the drugs used in this protocol or on recent use of sedatives, anti-depressants
7.Inability to assess muscle strength or TOF count (neuromuscular disease).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the time (in minutes) needed to achieve a TOF ratio of 0.9 after administering the study drug.Timepoint: 1. Preoperatively <br/ ><br>2. Induction <br/ ><br>3. Intubation <br/ ><br>4. Extubation
- Secondary Outcome Measures
Name Time Method 1. To assess clinical parameters of postoperative recovery <br/ ><br>a. Sustained head lift(yes/no) <br/ ><br>b. Sustained hand grip(yes/no) <br/ ><br>c. Exhaled Tidal volume(in ml) <br/ ><br>2. To assess length of Post Anesthesia Care Unit stay (in minutes) <br/ ><br>Timepoint: 1. Pre operatively <br/ ><br>2. Induction <br/ ><br>3. Intubation <br/ ><br>4. Extubation