Gastro-enteritis admissions in hospitals: incidence and aetiology
Completed
- Conditions
- gastro-enteritisstomach flu1001797710019815
- Registration Number
- NL-OMON31820
- Lead Sponsor
- Ministerie van Volksgezondheid, Welzijn en Sport (VWS)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1800
Inclusion Criteria
A person with complaints of diarrhoea and or vomiting, who is being submitted to the hospital
Exclusion Criteria
Not having diarrhoea or vomiting complaints, having had diarrhoea or vomiting complaints in the two weeks before the current episode, being younger than 2 weeks
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Incidence of gastroenteritis admissions.<br /><br><br /><br>Incidence of the following pathogens in patients hospitalised because of<br /><br>gastroenteritis:<br /><br>Bacteriology (RT-PCR): Salmonella, Shigella, Campylobacter, Yersinia,<br /><br>shigatoxin producing E. coli (STEC), entero-aggregative E. coli (EAggEC),<br /><br>enteropathogenic E. coli (EPEC) and Clostridium difficile<br /><br>Virology (RT-PCR): rota-, adeno-, astro-, noro- and sapovirus<br /><br>Parasitology (microscopy and ELISA): Cryptosporidium, Giardia and Dientamoeba<br /><br>fragilis.<br /><br><br /><br>The course of illness per pathogen in patients hospitalised because of<br /><br>gastroenteritis, including complications, chronic complaints and costs.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The DNA isolated from feces for detection of the pathogens will be used for<br /><br>determining genetic polymorphisms in these patients groups. This study will<br /><br>test genes involved in the specific immune response, in particular Th 1 genes,<br /><br>genes involved in innate immunity, and genes involved in inflammatory<br /><br>responses. The frequency of these polymorphisms will be compared to the<br /><br>frequencies determined in population controls in earlier studies. Furthermore,<br /><br>patients groups infected with different pathogens will be compared for<br /><br>frequencies of the polymorphisms.</p><br>