fMRI in Blood Phobia Syncope

Withdrawn

• Conditions: Syncope; Blood Injury Phobia; Autonomic Dysfunction

• Registration Number: NCT00715065
• Lead Sponsor: Vanderbilt University

Brief Summary

We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain activation in response to seeing bloody or gory pictures that occur before the fainting occurs.

Detailed Description

Another aim of the study is to determine whether or not differences in personality traits among people with blood phobia is associated with differences in BOLD signal responses during fMRI.

Study Timeline

• Study First Submitted: 2008-07-10
• Study First Submitted QC: 2008-07-14
• Study First Posted: 2008-07-15
• Study Start: 2010-06
• Primary Completion: 2010-06
• Study Completion: 2010-06
• Status Verified: 2013-01
• Last Update Submitted: 2013-01-07
• Last Update Posted: 2013-01-09

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• 18-30 years of age
• 1. History of at least one syncopal episode upon exposure to viewing blood (Case Group)
• Negative urine pregnancy test on study day

Exclusion Criteria

• Vasoactive medications (within 2 weeks of study day)
• antihypertensives
• beta blockers
• vasoconstrictors
• Psychotropic medications (within 4 weeks of study day)
• History of psychostimulant or opiate use
• History of alcohol, benzodiazepine or cannabis abuse or dependence

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
fMRI BOLD signal	Immediate

Secondary Outcome Measures

Name	Time	Method
Disgust Scale (Revised)	Single Visit
Blood Injection Symptoms Scale	Single visit

Trial Locations

Locations (1)

Vanderbilt University Autonomic Dysfunction Center; 🇺🇸 Nashville, Tennessee, United States