fMRI in Blood Phobia Syncope
Withdrawn
- Conditions
- SyncopeBlood Injury PhobiaAutonomic Dysfunction
- Interventions
- Procedure: fMRI Scan
- Registration Number
- NCT00715065
- Lead Sponsor
- Vanderbilt University
- Brief Summary
We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain activation in response to seeing bloody or gory pictures that occur before the fainting occurs.
- Detailed Description
Another aim of the study is to determine whether or not differences in personality traits among people with blood phobia is associated with differences in BOLD signal responses during fMRI.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- 18-30 years of age
-
- History of at least one syncopal episode upon exposure to viewing blood (Case Group)
- Negative urine pregnancy test on study day
Exclusion Criteria
- Vasoactive medications (within 2 weeks of study day)
- antihypertensives
- beta blockers
- vasoconstrictors
- Psychotropic medications (within 4 weeks of study day)
- History of psychostimulant or opiate use
- History of alcohol, benzodiazepine or cannabis abuse or dependence
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 2 fMRI Scan Healthy control subjects (who do not faint at the sight of blood) 1 fMRI Scan People who faint at sight of blood
- Primary Outcome Measures
Name Time Method fMRI BOLD signal Immediate
- Secondary Outcome Measures
Name Time Method Disgust Scale (Revised) Single Visit Blood Injection Symptoms Scale Single visit
Trial Locations
- Locations (1)
Vanderbilt University Autonomic Dysfunction Center
🇺🇸Nashville, Tennessee, United States