Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 499
- 主要终点
- Incidence of AKI
研究概览
简要总结
Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.
详细描述
Ethical approval was submitted and approved by the regional ethical committee, Etisk prövningsnämnd Uppsala, # 2017/418.
Patients were selected from the time span of april 2016 to september 2017. The investigators identified 499 patients that had undergone any of the selected procedures. The procedures were, pancreatic resection, HIPEC surgery in colorectal setting, gynecological debulking in metastasized ovarian cancer, and liver resection.
The risk of acute kidney injury (AKI) by the KDIGO definition during the postoperative period will be estimated in the group as a whole, and for each type of surgery separately. In addition the data will be stratified by sex to investigate systematic gender disparities or physiological differences. Length of stay, thirty day and sixty day mortality will secondary endpoints.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any of the selected procedures.
排除标准
- •Patient has expressed his or her will to nor participate in any study.
结局指标
主要结局
Incidence of AKI
时间窗: the first 24- 72 hours postop
Frequency of AKI as defined by KDIGO
次要结局
- Major Adverse Kidney Events(30, 60 and 360 days postoperatively)
- Mortality(30, 60 and 360 days postoperatively)
- Electrolyte disturbances(24-72h)
- Fluid balance(24-72h)
研究者
Michael Hultström
Associate professor
Uppsala University