Aerobic Exercise on Ventilatory Efficiency in CAD Patients

Phase 2

Completed

• Conditions: Coronary Artery Disease; Exercise Addiction; Complication, Cardio-respiratory

• Registration Number: NCT02106533
• Lead Sponsor: Hospital TotalCor

Brief Summary

The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

Detailed Description

Measurements of ventilatory efficiency during cardiorespiratory exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs. In addition, a growing body of studies has demonstrated that lower ventilatory efficiency during exercise is considered an important predictor of risk mortality, hospitalization, and other outcomes than peak VO2.

Study Timeline

• Study Start: 2011-08
• Primary Completion: 2012-06
• Study Completion: 2013-05
• Study First Submitted: 2014-03-27
• Status Verified: 2014-04
• Study First Submitted QC: 2014-04-07
• Last Update Submitted: 2014-04-07
• Study First Posted: 2014-04-08
• Last Update Posted: 2014-04-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 123

Inclusion Criteria

• was stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria

• unstable angina pectoris,
• complex ventricular arrhythmias,
• pulmonary congestion and
• orthopaedic or neurological limitations to exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Ventilatory efficiency in patients with coronary artery disease	up to 3 months of the interventions	Measurements of ventilatory efficiency during cardiopulmonary exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs.