Effects of Exercise in Patients With Coronary Artery Disease Aged 80 Years or Older

Not Applicable

Completed

• Conditions: Coronary Artery Disease
• Interventions: Other: Exercise

• Registration Number: NCT02025257
• Lead Sponsor: Sahlgrenska University Hospital, Sweden

Brief Summary

The purpose of this study is to investigate the effects of exercise for patients with coronary artery disease (CAD) aged 80 years and older, with special reference to maximum aerobic capacity, muscle endurance, physical functioning, level of physical activity, health related quality of life, anxiety, depression and endothelial function, compared to a control group.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-10-21
• Study Start: 2013-12
• Study First Submitted QC: 2013-12-27
• Study First Posted: 2014-01-01
• Primary Completion: 2019-05
• Status Verified: 2022-04
• Study Completion: 2022-04
• Last Update Submitted: 2022-04-10
• Last Update Posted: 2022-04-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Clinical diagnosis of acute coronary artery disease
• Aged 80 years or older

Exclusion Criteria

• Inability to understand or speak the Swedish language
• Serious physical or psychological disease interfering with participation in an exercise intervention
• Patients are already exercising three times or more/week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	Individually prescribed hospital based exercise in group two times a week, home-based exercise once a week. The exercise intervention consists of interval based aerobic exercise on a bicycle ergometer 30 minutes with intensity level at 13-17 at Borg scale, resistance exercises and balance exercises

Primary Outcome Measures

Name	Time	Method
Change in maximum aerobic capacity	At baseline and after 4 months	A maximum exercise test on an electronically braked cycle ergometer, with watts as marker of maximum aerobic capacity.

Secondary Outcome Measures

Name	Time	Method
Change in transthoracic evaluation of resting coronary flow velocity	At baseline and after 4 months
Change in health related quality of life	At baselline and after 4 months	measured by a self-rated health questionnaire
Change in anxiety and depression	At baseline and after 4 months	measured by the hospital anxiety and depression scale
Change in level of physical activity	At baseline and after 4 months	Level of physical activity will be measured by an accelerometer and an activity diary
Change in endothelial function	At baseline and after 4 months	Evaluated with non-invasive ultrasound
Change in muscular endurance	At baseline and after 4 months	Will be measured by three clinical endurance tests including unilateral isotonic heel lift, unilateral isotonic shoulder flexion, bilateral isometric shoulder abduction
Change in physical functioning	At baseline and after 4 months	Including tests of balance: short physical performance battery, one leg standing, timed up and go, and the activities specific balance confidence scale.

Trial Locations

Locations (1)

Department of physiotherapy, Sahlgrenska University Hospital; 🇸🇪 Gothenburg, Select A State…, Sweden