Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

Not Applicable

Completed

• Conditions: Headache
• Interventions: Drug: Carbachol

• Registration Number: NCT00564408
• Lead Sponsor: Danish Headache Center

Brief Summary

The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

Detailed Description

To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study

Study Timeline

• Study Start: 2007-08
• Study First Submitted: 2007-11-27
• Study First Submitted QC: 2007-11-27
• Study First Posted: 2007-11-28
• Primary Completion: 2008-10
• Study Completion: 2009-02
• Status Verified: 2009-07
• Last Update Submitted: 2009-07-31
• Last Update Posted: 2009-08-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Migraine without aura
• Weight 50-100 kg

Exclusion Criteria

• Other significant diseases
• Migraine 5 days prior to experiment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
I	Carbachol	-

Primary Outcome Measures

Name	Time	Method
Headache response after Carbachol infusion	1 day after infusion

Trial Locations

Locations (1)

Danish Headache Center; 🇩🇰 Glostrup, Denmark