The prediction of neutrophil recovery by increasing monocyte count, A prospective study

• Conditions: Chemotherapy induced neutropenia in solid cancer patients; Chemotherapy induced neutropenia; Monocyte count; Neutrophil count

• Registration Number: TCTR20210722005
• Lead Sponsor: Medical oncology unit, Faculty of medicine, Chulalongkorn university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-22
• Study Completion: 2022-02-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

solid cancer patients with during chemotherapy any regimen in 2 or 3 week interval
- first time of absolute neutrophil count less than 1500 cell/mm3 in day of next cycle or before 24 hour of next cycle
- postpone chemotherapy by individual physician
- patients can follow up complete blood count (CBC) in next 3 day
- ECOG 0-2

Exclusion Criteria

- previous radiation within 30 days
- bone marrow metastasis
- receive prophylaxis granulocyte colony-stimulating factor (G-CSF)
- receive systemic immunosuppressive medications
- active infection
- BMI less than 18.5 kg/m2

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eutrophil recovery next 3 days Proportion

Secondary Outcome Measures

Name	Time	Method
eutrophil recovery in patients with monocyte more than 15% next 3 days Proportion,Neutrophil recovery in patients with absolute monocyte count more than 400 cell/mm3 next 3 days Proportion,Relationship of monocyte count and neutrophil recovery next 3 days receiver operating characteristic curve (ROC)