Adrenaline During Resuscitation From Pulseless Electrical Activity

Completed

• Conditions: Heart Arrest

• Registration Number: NCT04149730
• Lead Sponsor: St. Olavs Hospital

Brief Summary

This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. Aim is to investigate the changes in electrocardiograms (ECG) during resuscitation from pulseless electrical activity (PEA), which is a type of cardiac arrest. ECG changes may be useful as a prognostic marker during resuscitation from PEA. In addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. Clinical state transitions are changes between different types of cardiac arrest. This study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-20
• Study First Submitted: 2019-10-18
• Study First Submitted QC: 2019-10-31
• Study First Posted: 2019-11-04
• Primary Completion: 2023-01-01
• Study Completion: 2023-05-15
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-01
• Last Update Posted: 2023-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 280

Inclusion Criteria

Cardiac arrest among hospitalized patients presenting with PEA as the primary rhythm.

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes of clinical states	Every 3 minutes from start till end of cardiopulmonary resuscitation	changes of clinical states (for example from Pulseless electrical activity to Ventricular fibrillation) during treatment of cardiac arrest.
QRS frequency	Every 3 minutes from start till end of cardiopulmonary resuscitation	Measurement of RR intervals in milliseconds.
QRS width	Every 3 minutes from start till end of cardiopulmonary resuscitation	Measurement of the width of QRS complexes in milliseconds

Trial Locations

Locations (2)

St Olavs Hospital; 🇳🇴 Trondheim, Norway

Hospital of the University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States