Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease Moderate

• Registration Number: NCT03020862
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Detailed Description

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Study Timeline

• Study Start: 2013-12
• Primary Completion: 2014-04
• Status Verified: 2014-06
• Study Completion: 2015-08
• Study First Submitted: 2017-01-11
• Study First Submitted QC: 2017-01-12
• Study First Posted: 2017-01-13
• Last Update Submitted: 2017-01-13
• Last Update Posted: 2017-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 <80% of predicted).

Exclusion Criteria

• Smoking,
• failure to complete physical testing,
• on-going participation in rehabilitation programs,
• pacemaker or use of nicotine products,
• oxygen mask,
• beta blockers,
• antibacterial mouthwash,
• chewing gum or stomach-neutralizing medicine during the intervention.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Physical performance on 6-min walk test (6MWT)	6 minutes

Secondary Outcome Measures

Name	Time	Method
Physical activity level	Six days	Measured all intervention days except on the day of testing
Oxygen consumption during submaximal cycling	Two trials of 6 minutes duration (10 min break between trials)
Plasma Nitrite concentration	Baseline, 150 and 210 minutes after consumption of beverages
Blood Pressure	At baseline and 150 minutes after consumption of beverages

Trial Locations

Locations (1)

Sport Science, Department of Public Health, Aarhus University; 🇩🇰 Aarhus, Denmark