escitalopram in depressive patients with acute coronary artery syndrome

Not Applicable

Recruiting

• Conditions: Mental and behavioral disorders

• Registration Number: KCT0000053
• Lead Sponsor: Chonnam National University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

1)Aged 18~85
2)Diagnosed as acute CAS (unstable angina or acute myocardial infarction) and being conducted coronary angiography
3)Beck Depression Inventory > 10 and major or minor depressive disorder by the DSM-IV criteria
4)With ability to complete various questionnaires
5)Can understand the objective of the study and sign informed consent

Exclusion Criteria

1)Occurrence of acute CAS while the patient was hospitalized for another reason, except for CAS
2)Current CAS developed less than 3 months after coronary artery bypass graft procedure
3)Uncontrolled hypertension (systolic BP > 180mmHg or diastolic BP > 100mmHg)
4)Resting heart rate < 40/min
5)Severe physical illnesses threatening life or interfering with the recovery from CAS
6)Persistent clinically significant laboratory abnormalities
7)Concomitant use of class I antiarrhythmic medications; reserpine, guanethidine, clonidine, or methyldopa; anticonvulsants or neuroleptics
8)History of neuropsychiatric illnesses such as dementia, Parkinson's disease, brain tumor, psychoses, alcoholism, and other substance dependence
9)Pregnancy

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Score on the Hamilton Depression Rating Scale-17 item [ Time Frame: 24 weeks ]

Secondary Outcome Measures

Name	Time	Method
scores on the Beck Depression Inventory (BDI);scores on the Montgomery Asberg Depression Rating Scale (MADRS);Clinical Global Impression (CGI)