DNA Methylation and Urothelial Carcinoma

• Conditions: Urothelial Carcinoma

• Registration Number: NCT01378052
• Lead Sponsor: China Medical University Hospital

Brief Summary

Many studies previously showed the significant association between urinary arsenic profiles and urothelial carcinoma (UC) risk and observed the increased UC risk in people with lower plasma folate and higher homocysteine than those with higher plasma folate and lower homocysteine. The investigators would expect to explore the interactions among global DNA methylation, one-carbon metabolic pathway factors, urinary arsenic profiles and UC.

Detailed Description

Not available

Study Timeline

• Status Verified: 2011-06
• Study Start: 2011-06
• Study First Submitted: 2011-06-20
• Study First Submitted QC: 2011-06-21
• Last Update Submitted: 2011-06-21
• Study First Posted: 2011-06-22
• Last Update Posted: 2011-06-22
• Primary Completion: 2012-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Clinical diagnosis of urothelial carcinoma
• The voluntary of participating the study

Exclusion Criteria

• Age smaller than 20 years
• Pregnant women
• Not willing to participate the study because of their personal reasons

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
urothelial carcinoma	one year	Pathological verification of UC was done by routine urological practice including endoscopic biopsy or surgical resection of urinary tract tumors followed by histopathological examination by board-certified pathologists.

Trial Locations

Locations (1)

Department of Urology, China Medical University Hospital; 🇨🇳 Taichung, 404, Taiwan