The Effectiveness of Vancomycin in Comarison With Cefazolin in Prevention of SSI After Craniotomy
Phase 1
- Conditions
- Elective Craniotomy-candidated Patients
- Interventions
- Registration Number
- NCT03466645
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Surgical-site infection is the most commonly reported nosocomial infection in patients undergoing surgery and 3rd most nosocomial infection in hospitalized patients. The SSI is associated with increases of length of hospitalization for 6 days and increases the hospital's cost by $ 300.
Because of these, prevention of SSI with appropriate antibiotic is essential.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 126
Inclusion Criteria
- age 18 years and above
- elective surgical patients
- No pre-surgery infection
- Do not use antibiotics before surgery
- Insensitivity to beta-lactam antibiotics
Exclusion Criteria
- cranioplasty
- Failure to follow the patient
- The patient's unwillingness to continue participating in the research project
- Death of the patient
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1st group, receiving vancomycin Vancomycin The 1st group receives vancomycin an hour before craniotomy 2nd group, receiving cefazolin Cefazolin The 2nd group receives cefazolin an hour before craniotomy
- Primary Outcome Measures
Name Time Method infection rate Until 90 days after admission compare of infection rate in 2 groups
- Secondary Outcome Measures
Name Time Method length of hospitalization Until 90 days after admission compare the length of hospitalization in 2 groups
raise of ESR & CRP Until 90 days after admission compare the raise of ESR \& CRP in 2 groups
Trial Locations
- Locations (1)
Isfahan university of medical science.
🇮🇷Isfahan, Iran, Islamic Republic of