Vancomycin

Generic Name: Vancomycin

Brand Names: Firvanq, Vancocin

Drug Type: Small Molecule

Chemical Formula: C_₆₆H_₇₅Cl_₂N_₉O_₂₄

CAS Number: 1404-90-6

Unique Ingredient Identifier: 6Q205EH1VU

Background: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
...

Indication: Administered intravenously, vancomycin is indicated in adult and pediatric patients for the treatment of septicemia, infective endocarditis, skin and skin structure infections, bone infections, and lower respiratory tract infections. Administered orally, vancomycin is indicated in adult and pediatric patients for the treatment of Clostridium difficile-associ...

Associated Conditions: Clostridium Difficile Associated Diarrhea (CDAD), Enterocolitis caused by Staphylococcus aureus, Infection caused by staphylococci, Severe Staphylococcal infection

Associated Therapies: -

Clinical Trials

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

Phase 2

Not yet recruiting

Conditions: Primary Total Knee Arthroplasty
Intraosseous Morphine Injection
Knee Osteoarthritis

Interventions: Drug: Vancomycin
Drug: Morphine

First Posted Date: 2024-12-04

Last Posted Date: 2024-12-04

Lead Sponsor: Carilion Clinic

Target Recruit Count: 86

Registration Number: NCT06716749

Locations: 🇺🇸
Carilion Clinic, Roanoke, Virginia, United States

Clostridioides Difficile Controlled Human Infection Model

Not Applicable

Not yet recruiting

Conditions: C. Difficile
C. Difficile Infection
Controlled Human Infection

Interventions: Other: encapsulated 10^4 CFU toxigenic. C. difficile spores
Drug: Vancomycin
Drug: Clindamycin

First Posted Date: 2024-11-22

Last Posted Date: 2024-11-22

Lead Sponsor: Leiden University Medical Center

Target Recruit Count: 60

Registration Number: NCT06702345

Locations: 🇳🇱
Leiden University Medical Center, Leiden, Zuid Holland, Netherlands

A Phase 1b Trial to Evaluate the Safety of MB310 in Patients With Active, Mild-to-Moderate Ulcerative Colitis

Phase 1

Recruiting

Conditions: Ulcerative Colitis

Interventions: Biological: MB310
Other: Placebo
Drug: Vancomycin

First Posted Date: 2024-09-03

Last Posted Date: 2024-11-27

Lead Sponsor: Microbiotica Ltd

Target Recruit Count: 30

Registration Number: NCT06582264

Locations: 🇦🇹
Medizinische Universitaet Innsbruck, Innsbruck, Austria
🇦🇹
Klinikum Klagenfurt am Woerthersee, Klagenfurt, Austria
🇦🇹
Uniklinikum Salzburg, Salzburg, Austria

and more 15 locations

Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial

Phase 4

Not yet recruiting

Conditions: Infection, Surgical Site

Interventions: Drug: Cefazolin
Drug: Vancomycin

First Posted Date: 2024-08-23

Last Posted Date: 2024-08-23

Lead Sponsor: Hamilton Health Sciences Corporation

Target Recruit Count: 38000

Registration Number: NCT06567808

Pharmacokinetics Vancomycin CVVHDF With oXiris Membrane

Not Applicable

Not yet recruiting

Conditions: AKI - Acute Kidney Injury

Interventions: Drug: Vancomycin

First Posted Date: 2024-08-09

Last Posted Date: 2024-08-09

Lead Sponsor: Mahidol University

Target Recruit Count: 8

Registration Number: NCT06543940

Locations: 🇹🇭
Facullty of Pharmacy Mahidol University, Bangkok, Payathi, Thailand

A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients

Phase 1

Recruiting

Conditions: Melanoma

Interventions: Biological: MB097
Biological: Pembrolizumab
Drug: Vancomycin

First Posted Date: 2024-08-06

Last Posted Date: 2024-12-16

Lead Sponsor: Microbiotica Ltd

Target Recruit Count: 40

Registration Number: NCT06540391

Locations: 🇫🇷
Centre Georges Francois Leclerc, Dijon, France
🇫🇷
CHU de Lille - Hopital Claude Huriez, Lille, France
🇫🇷
Centre Leon Berard, Lyon, France

and more 16 locations

Pulsed Electromagnetic Field Stimulation and Charcot Foot Ulcer

Not Applicable

Recruiting

Conditions: Charcot Foot Ulcer

Interventions: Device: pulsed electromagnetic field therapy
Device: Transcutanous electrical nerve stimulation
Drug: Vancomycin

First Posted Date: 2024-07-30

Last Posted Date: 2024-07-30

Lead Sponsor: Cairo University

Target Recruit Count: 34

Registration Number: NCT06527131

Locations: 🇪🇬
Physical Therapy Cairo University, Giza, Egypt

Irrisept Solution for Instrumented Spine Surgery

Not Applicable

Recruiting

Conditions: Post-Op Complication
Spine Surgery
Site Infection
Surgical Site Infection
Spinal Instrumentation
Index Spinal Instrumentation
Layer-by-Layer Closure
Locoregional Flap-Based Closure

Interventions: Device: Chlorhexidine gluconate solution
Drug: Vancomycin

First Posted Date: 2024-06-03

Last Posted Date: 2024-11-20

Lead Sponsor: Rhode Island Hospital

Target Recruit Count: 200

Registration Number: NCT06439953

Locations: 🇺🇸
Rhode Island Hospital, Providence, Rhode Island, United States

Haemoglobin And Vancomycin Pharmacokinetics in the Cerebrospinal Fluid Following Subarachnoid Haemorrhage

Not Applicable

Not yet recruiting

Conditions: Subarachnoid Hemorrhage

Interventions: Procedure: Insertion of drains
Drug: Vancomycin

First Posted Date: 2024-04-18

Last Posted Date: 2024-04-18

Lead Sponsor: University Hospital Southampton NHS Foundation Trust

Target Recruit Count: 14

Registration Number: NCT06373640

Infection Rates Between Using of Vancomycin Versus Gentamycin in Primary ACLR

Not yet recruiting

Conditions: Anterior Cruciate Ligament Injuries

Interventions: Drug: Vancomycin

First Posted Date: 2023-09-22

Last Posted Date: 2024-02-05

Lead Sponsor: Assiut University

Target Recruit Count: 110

Registration Number: NCT06050785

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