Daptomycin

Generic Name
Daptomycin
Brand Names
Cubicin, Dapzura, Daptomycin Hospira
Drug Type
Small Molecule
Chemical Formula
C72H101N17O26
CAS Number
103060-53-3
Unique Ingredient Identifier
NWQ5N31VKK
Background

Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant Staphylococcus aureus (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE). Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-te...

Indication

Daptomycin is indicated for the treatment of complicated skin and skin structure infections (cSSSI) in patients one year of age and older. It is also indicated for the treatment of Staphylococcus aureus bloodstream infections (bacteremia) in patients one year of age and older, including in adult patients with right-sided infective endocarditis.
...

Associated Conditions
Complicated Skin and Skin Structure Infection, Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
Associated Therapies
-

PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

First Posted Date
2021-07-30
Last Posted Date
2024-11-04
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
100
Registration Number
NCT04983901
Locations
🇺🇸

M D Anderson Cancer Center, Houston, Texas, United States

DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia

First Posted Date
2021-03-01
Last Posted Date
2024-12-10
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
200
Registration Number
NCT04775953
Locations
🇺🇸

Corewell Health - Infectious Disease, Royal Oak, Michigan, United States

🇺🇸

University of Alabama Hospital - Infectious Diseases, Birmingham, Alabama, United States

🇺🇸

University of California Davis Medical Center - Internal Medicine - Infectious Disease, Sacramento, California, United States

and more 21 locations

The Efficacy and Safety of Daptomycin in the Treatment of Gram-positive Bacterial Infection.

Conditions
Interventions
First Posted Date
2020-09-14
Last Posted Date
2020-09-17
Lead Sponsor
Jiangsu Hengrui Pharmaceutical Co., Ltd.
Target Recruit Count
2000
Registration Number
NCT04546815
Locations
🇨🇳

Peking Union Medical College Hospital, Beijing, Beijing, China

Subcutaneous Daptomycin in Healthy Volunteers (DAPTOSC)

First Posted Date
2020-06-16
Last Posted Date
2022-02-01
Lead Sponsor
University Hospital, Caen
Target Recruit Count
12
Registration Number
NCT04434300
Locations
🇫🇷

CHU Caen, Caen, Normandie, France

A Pharmacokinetics Study of Daptomycin in Critically Ill Patients and Effects of Daptomycin on Kidney

First Posted Date
2020-02-20
Last Posted Date
2020-11-13
Lead Sponsor
Zhongnan Hospital
Target Recruit Count
120
Registration Number
NCT04277143
Locations
🇨🇳

Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)

First Posted Date
2019-10-18
Last Posted Date
2021-07-21
Lead Sponsor
Azienda Sanitaria-Universitaria Integrata di Udine
Target Recruit Count
104
Registration Number
NCT04132115
Locations
🇮🇹

Anesthesiology and Intensive Care Clinic - Department of Medicine - ASUIUD, Udine, Italy

🇮🇹

Terapia Intensiva 1, Udine, Italy

Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis

Phase 2
Completed
Conditions
Interventions
First Posted Date
2018-03-29
Last Posted Date
2024-10-01
Lead Sponsor
Centre Hospitalier Universitaire Dijon
Target Recruit Count
112
Registration Number
NCT03480191
Locations
🇫🇷

CHU Dijon Bourgogne, Dijon, France

Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremia

First Posted Date
2017-05-03
Last Posted Date
2023-11-08
Lead Sponsor
Basilea Pharmaceutica
Target Recruit Count
390
Registration Number
NCT03138733
Locations
🇺🇸

Remington Davis Inc., Columbus, Ohio, United States

🇮🇹

Giuliano Isontina University Health Authority, Trieste, Italy

🇮🇱

The Baruch Padeh Medical Center, Poriyya 'Illit, Israel

and more 57 locations

Daptomycin Concentration in Drainage Fluid and Blood Samples of ICU Patients

Completed
Conditions
First Posted Date
2016-12-28
Last Posted Date
2019-04-19
Lead Sponsor
University Hospital Tuebingen
Target Recruit Count
9
Registration Number
NCT03004066
Locations
🇩🇪

University Hospital Tuebingen, Tuebingen, Germany

Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremia

First Posted Date
2016-11-25
Last Posted Date
2020-09-22
Lead Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Target Recruit Count
102
Registration Number
NCT02972983
Locations
🇨🇦

McGill University Health Centre (Royal Victoria Hospital, Montreal Neurological Hospital, and Montreal General Hospital), Montreal, Quebec, Canada

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