Daptomycin
- Generic Name
- Daptomycin
- Brand Names
- Cubicin, Dapzura, Daptomycin Hospira
- Drug Type
- Small Molecule
- Chemical Formula
- C72H101N17O26
- CAS Number
- 103060-53-3
- Unique Ingredient Identifier
- NWQ5N31VKK
- Background
Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant Staphylococcus aureus (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE). Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-te...
- Indication
Daptomycin is indicated for the treatment of complicated skin and skin structure infections (cSSSI) in patients one year of age and older. It is also indicated for the treatment of Staphylococcus aureus bloodstream infections (bacteremia) in patients one year of age and older, including in adult patients with right-sided infective endocarditis.
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- Associated Conditions
- Complicated Skin and Skin Structure Infection, Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
- Associated Therapies
- -
Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatment
- First Posted Date
- 2010-09-13
- Last Posted Date
- 2024-03-18
- Lead Sponsor
- Ruhr University of Bochum
- Target Recruit Count
- 1
- Registration Number
- NCT01199783
- Locations
- 🇩🇪
Herz- und Diabeteszentrum, Bad Oeynhausen, Germany
Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2010-09-08
- Last Posted Date
- 2014-02-03
- Lead Sponsor
- Mountain Home Research & Education Corporation
- Target Recruit Count
- 28
- Registration Number
- NCT01196169
- Locations
- 🇺🇸
Johnson City Medical Center, Johnson City, Tennessee, United States
🇺🇸James H Quillen VA Medical Center, Mountain Home, Tennessee, United States
Study to Compare Efficacy and Safety of Daptomycin in Elderly Patients With Complicated Skin and Soft Tissue Infections
- Conditions
- Interventions
- First Posted Date
- 2010-08-19
- Last Posted Date
- 2012-07-13
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 120
- Registration Number
- NCT01184872
- Locations
- 🇪🇸
Novartis Investigative Site, Seville, Spain
🇷🇺Novartis Investigative Site (2), Saint Petersburg, Russian Federation
🇪🇸Novartis Investigative Site (1), Madrid, Spain
Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Setting
- Conditions
- Interventions
- First Posted Date
- 2010-08-05
- Last Posted Date
- 2018-12-26
- Target Recruit Count
- 80
- Registration Number
- NCT01175707
- Locations
- 🇺🇸
Heartland I.V. Care, Pittsburgh, Pennsylvania, United States
🇺🇸NationsMed Clinical Research, Inc., Stafford, Texas, United States
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltration
- Conditions
- First Posted Date
- 2010-07-28
- Last Posted Date
- 2010-07-28
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 15
- Registration Number
- NCT01171547
- Locations
- 🇨🇭
Medical Intensive Care Unit, University Hospital Zurich, Zurich, Switzerland
Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection
- First Posted Date
- 2010-06-15
- Last Posted Date
- 2012-06-26
- Lead Sponsor
- Andrej Trampuz
- Target Recruit Count
- 60
- Registration Number
- NCT01144000
- Locations
- 🇨🇭
Schulhess Clinic, Zurich, Switzerland
🇨🇭Centre hospitaliere universitaire vaudois (CHUV), Lausanne, Vaud, Switzerland
🇨🇭Kantonsspital, Liestal, Switzerland
Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment
- Conditions
- Interventions
- First Posted Date
- 2010-04-15
- Last Posted Date
- 2018-09-05
- Target Recruit Count
- 92
- Registration Number
- NCT01104662
Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections
- First Posted Date
- 2010-03-05
- Last Posted Date
- 2012-04-17
- Lead Sponsor
- Hannover Medical School
- Target Recruit Count
- 650
- Registration Number
- NCT01080963
- Locations
- 🇩🇪
Hannover Medical School, Department of Cardiothoracic, Transplant and Vascular surgery, Hannover, Germany
Cerebrospinal Fluid Pharmacokinetics of Daptomycin
- First Posted Date
- 2009-12-03
- Last Posted Date
- 2013-08-12
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 2
- Registration Number
- NCT01025271
- Locations
- 🇺🇸
UPMC, PIttsburgh, Pennsylvania, United States
Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics
- First Posted Date
- 2009-11-25
- Last Posted Date
- 2019-11-13
- Target Recruit Count
- 23
- Registration Number
- NCT01019395
- Locations
- 🇺🇸
University of Louisiana at Monroe, Shreveport, Louisiana, United States
🇺🇸Cook Children's Medical Center, Fort Worth, Texas, United States
🇺🇸University Hospitals Case Medical Center, Cleveland, Ohio, United States
Drug Development Updates
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