Serotonin Role on Brain Circuits Involved in Food Avoidance in Anorexia Nervosa
- Conditions
- Anorexia Nervosa
- Interventions
- Other: PET imaging using [11C]DASB radioligand.Behavioral: Eye Tracker
- Registration Number
- NCT05155280
- Brief Summary
Serotoninergic activity in brain structures involved in food control and avoidance, such as the basal ganglia, is poorly understood in Anorexia Nervosa.
- Detailed Description
A simultaneous positron emission tomography (PET)- functional magnetic resonance imaging (fMRI) approach and testing of food preferences and choices will provide further insight into the link between potential abnormalities in serotoninergic transmission and the specific food restriction disorder for Anorexia Nervosa. These Data can pave the way for new therapeutic avenues.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 75
Patients with restrictive anorexia nervosa (30 subjects).
- Anorexia nervosa common features : fear of weight gain, dysmorphophobia, BMI < 17.5 kg/ m², amenorrhea
- Absence of food compulsions and purges
- Subgroup 1 (15 subjects) : STAI Y2 anxiety score > 61
- Subgroup 2 (15 subjects) : STAI Y2 anxiety score < 51
Inclusion criteria - Female control subjects (15 subjects)
- BMI between 18.5 and 25 kg/ m²
- Absence of a psychological profile of eating disorder or other psychiatric disorders.
- Subjects with an oral contraception and breastfeeding woman
- Subject with heart failure
- Subject treated during the last three months with neuroleptics, and antiparkinsonian drugs, monoamine oxidase (MAO)-A or monoamine oxidase (MOA)-B inhibitors, tricyclic antidepressants, 5HT reuptake inhibitors, thymo regulators (lithium), antiepileptic dugs, codeine derivatives, morphinics, tramadol-containing products (Topalgic, ...),dopaminergic drugs.
- Subjects with suspected pregnancy; Test β human chorionic gonadotropin (HCG) positive prior to examination.
- Subjects for whom MRI is contraindicated (pacemaker, intracerebral clips, prosthesis made of ferromagnetic material or claustrophobia).
- Subjects unable to sign written consent for participation in the study.
- Subject deprived of liberty by a judicial or administrative decision
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Anorexia Nervosa patients PET imaging using [11C]DASB radioligand. 30 patients with anorexia nervosa = 15 with moderate to high anxiety (STAI YB anxiety (STAI YB \> 51) and 15 with low anxiety (STAI YB\<51). A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2. Controls PET imaging using [11C]DASB radioligand. 15 healthy volunteers (control group) and a low level of anxiety trait (\< 51) A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2. Controls Eye Tracker 15 healthy volunteers (control group) and a low level of anxiety trait (\< 51) A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2. Anorexia Nervosa patients Eye Tracker 30 patients with anorexia nervosa = 15 with moderate to high anxiety (STAI YB anxiety (STAI YB \> 51) and 15 with low anxiety (STAI YB\<51). A TOBII eye tracker will be realised at Day 1. PET and MRI scans will be acquired at Day 2.
- Primary Outcome Measures
Name Time Method difference between the two groups of the study for serotonin binding potential Day 2 The difference in serotonin binding potential is measured by PET scan of the brain networks between anorexic and control subjects.
- Secondary Outcome Measures
Name Time Method correlation between abnormalities in serotonin binding potential and abnormalities in brain activity during the food choice tasks. Day 2 serotonin binding potential is measured with \[11C\]DASB PET. abnormalities in brain activity is measured on fMRI. correlation between abnormalities in serotonin binding potential and abnormalities in brain activity is quantified by change during the food choice tasks.
correlation between anxiety profile and brain activity Day 2 brain activity is measured on fMRI and anxiety is measured by the score STAI YB.
STAI YB \> 51 = Moderate to high anxiety STAI YB\<51 = Low anxietycorrelation between abnormalities in serotonin binding potential and abnormalities in brain activity in resting state Day 2 serotonin binding potential is measured with \[11C\]DASB PET. abnormalities in brain activity is measured on fMRI. correlation between abnormalities in serotonin binding potential and abnormalities in brain activity is quantified by change in the resting state
Trial Locations
- Locations (1)
CHU de Saint-Etienne
🇫🇷Saint-Étienne, France