Role of Oxytocin in Telling and Detecting Lies

Early Phase 1

Withdrawn

• Conditions: Dyssocial Behavior
• Interventions: Drug: Oxytocin

• Registration Number: NCT02361177
• Lead Sponsor: University of Texas at Austin

Brief Summary

The investigators are interested in the impact of intranasal oxytocin in unethical behavior.

Detailed Description

The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior. Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons. It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion. In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.

Study Timeline

• Study First Submitted: 2015-02-05
• Study First Submitted QC: 2015-02-10
• Study First Posted: 2015-02-11
• Study Start: 2016-01
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-09
• Last Update Posted: 2016-06-13

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Male
• Target Recruitment: Not specified

Inclusion Criteria

• Male

Exclusion Criteria

• _____ _____BP > 130/85, HRT > 95 (can be included at discretion of study physician/designee)

  • _____History of seizures
  • _____Neurological Disorder
  • _____Current psychiatric disorder
  • _____Previous psychiatric disorder (can be included at discretion of PI)
  • Date last episode (if > 1 year, include; if <1 year, at discretion of PI)
  • _____Current use of psychoactive drugs
  • Previous use of psychoactive drugs (can be included at discretion of PI) Date last medicated Type of medication_________________________
  • _____Current use of anticoagulants
  • _____Current use of corticosteroids
  • _____Previous head trauma (can be included at discretion of PI)
  • _____Alcoholism or substance abuse
  • _____Carcinoma of the breast or prostate
  • _____Renal or Hepatic diseases
  • _____Chronic lung diseases
  • _____Cancer
  • _____Liver problems
  • _____Hypertension/Cardiac diseases
  • _____Cardiovascular Disease
  • _____Nephritis
  • _____Diabetes (use of insulin) /Obesity
  • _____Endocrine disease or malignancy
  • _____Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
  • Medication
  • Frequency of episodes____ Date of last episode
  • _____Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
  • Medication Frequency of migraines Date of last migraine
  • _____High levels of physical contact with women or children

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oxytocin	Oxytocin	Intranasal 24 IU oxytocin self-administration.
placebo	Oxytocin	Intranasal placebo. 125 mg of 0.5% cholorobutanol to 50 ml saline, with approximately 5 pH. The solution will then be sterilized using a 0.22 micron filter.

Primary Outcome Measures

Name	Time	Method
Unethical behavior	130 minutes	To measure unethical behavior, we will calculate whether participants took more money than they actually earned on a problem-solving task.