Does Perioperative Pregabalin Reduce Postoperative Pain After Arthroscopic Anterior Cruciate Ligament Reconstruction Surgery Under Spinal Anesthesia?
Not Applicable
Completed
- Conditions
- Anterior Cruciate Ligament (ACL) Reconstruction
- Interventions
- Drug: placebo
- Registration Number
- NCT03211728
- Lead Sponsor
- Yonsei University
- Brief Summary
The investigators hypothesize that perioperative oral administration of pregabalin would reduce postoperative pain and produce reduction in postoperative opioid consumption after anterior cruciate ligament (ACL) reconstruction . Patients are randomly assign to 1 of 2 groups. The placebo group receive placebo capsules 1 hour before surgery and 12 hours after initial dose. The pregabalin group receive pregabalin 150 mg, respectively at the same points.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
Inclusion Criteria
- age between 20-65 years
- physical condition type I or II in ASA (American Society of Anesthesiology)
Exclusion Criteria
- patients of ASA classification 3 or more
- with a history of cardiovascular or respiratory disease
- dizziness or frequent headache
- active alcohol or drug usage,
- intake of any analgesics daily or 48 hours before surgery
- impaired renal and/or hepatic function
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description experimental group pregabalin - placebo group placebo -
- Primary Outcome Measures
Name Time Method Postoperative pain scores 2 weeks after surgery Visual analog scale (VAS) score = 0-100 mm
- Secondary Outcome Measures
Name Time Method Opioid consumption the first 48 hours after surgery
Trial Locations
- Locations (1)
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine
🇰🇷Seoul, Korea, Republic of