Observational - Relationships Between Tumor-Associated Macrophages and Clinicopathological Factors in Wilms Tumor
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Wilms Tumor and Other Childhood Kidney Tumors
- Sponsor
- Children's Oncology Group
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Relationship of tumor-associated macrophages and prognosis
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This research study is studying biomarkers in tissue samples from younger patients with Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment
Detailed Description
PRIMARY OBJECTIVES: I. To determine whether recruitment of tumor-associated macrophages is related to clinicopathological factors in Wilms tumor (tumor stage, presence of vascular invasion, tumor progression, and survival). OUTLINE: Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Wilms tissue microarray samples provided by the Children's Oncology Group
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Relationship of tumor-associated macrophages and prognosis
Time Frame: 1 month
Correlation of each type of macrophage score with tumor staging, presence of vascular invasion, and disease-free survival will be assessed.