The effect of mouthwash containing Zataria multiflora essence 2% on the prevention of ventilator-associated pneumonia

Not Applicable

• Conditions: Ventilator-associated pneumonia.; ventilator-associated pneumonia; J95.851

• Registration Number: IRCT20210523051370N6
• Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 29 August 2022

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patients aged 18-65 years
Having a tracheal tube
<12 hours elapsed since ICU admission
Having natural teeth

Exclusion Criteria

Patients with tracheostomy tube
A history of taking antibiotics during the last two weeks
A history of allergy to chlorhexidine and herbal mouthwashes
Reintubation
Severe maxillofacial trauma
Cervical spine immobilization
Pregnant and lactating women
A history of malignancy and cancer
A history of head and neck radiotherapy
A history of oral mucositis and periodontal diseases
Patients diagnosed with sepsis
Patients with immune system disorders
Patients with lung diseases (including pneumonia, asthma, and allergic rhinitis)
Simultaneously participating in other interventional studies
Patients with COVID-19 in admission
Withdrawal criteria: patient death; patients transferred to the ward or other hospitals; reintubation; side effects associated with the use of either mouthwash; oral mucositis and periodontal diseases; sepsis; unwillingness to continue participation in the study; eligibility criteria violated

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical Pulmonary Infection Score. Timepoint: Clinical Pulmonary Infection Score on first, third and fifth days of mouthwash use. Method of measurement: Pulmonary of Infection Survey Questionnaire.