Can fish oil supplementation improve endothelial function in asymptomatic offspring of patients with peripheral arterial disease?
Not Applicable
Recruiting
- Conditions
- Peripheral Arterial DiseaseCardiovascular - Diseases of the vasculature and circulation including the lymphatic systemAlternative and Complementary Medicine - Other alternative and complementary medicine
- Registration Number
- ACTRN12611000996965
- Lead Sponsor
- Flinders University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
To be included in the study, participants must have a parent with PAD, be aged 18 years and above, have impaired endothelial function and normal ABPI’s.
Exclusion Criteria
Patients will be excluded if they (1) ingest 2g or more of total omega 3 daily as per Fish Food Frequency Questionnaire, (2) have a seafood allergy, (3) life expectancy less than 12 weeks, (4) are unable to communicate effectively to provide informed consent, (5) are receiving treatment doses of any antithrombotic agent or (6) receiving dual anti-platelet function drugs (such as aspirin plus clopidogrel or prasugrel or ticlopidine), or (7) are diagnosed with a bleeding disorder such as von Willebrand disease or haemophilia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endothelium-mediated changes in vascular tone as measured by brachial artery flow-mediated dilatation.[Baseline, 6 and 12 weeks.]
- Secondary Outcome Measures
Name Time Method Inflammation as measured by CRP, absolute neutrophil and lymphocyte values, TNF-alpha, IL-1 and IL-6.[Baseline, 6 and 12 weeks.]