Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome
Not Applicable
Completed
- Conditions
- Endothelial Dysfunction
- Interventions
- Diagnostic Test: ENDOPAT
- Registration Number
- NCT04459182
- Lead Sponsor
- University Hospital, Angers
- Brief Summary
Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.
- Detailed Description
The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion.
the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI \>15).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 99
Inclusion Criteria
- adult subject
- Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent
- Subject with OSA (defined by AHI >15/h)
Exclusion Criteria
- cardiac or vascular desease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description No endothelial dysfunction (DE-) ENDOPAT obsese patient with OSA (AHI\>15) and no endothelial dysfunction Endothelial dysfunction (DE+) ENDOPAT obsese patient with OSA (AHI\>15) and endothelial dysfunction
- Primary Outcome Measures
Name Time Method miRNA cointained in exosomes immediately after the consultation compare exosome content between obese-OSA patients with endothelial dysfunction and without
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Frédéric GAGNADOUX
🇫🇷Angers, France