Is antibiotic treatment effective in the management of chronic low back pain? A clinical trial.

Phase 2

Completed

• Conditions: ow back pain with lumbar disc herniation; Low back pain with lumbar disc herniation; Musculoskeletal - Other muscular and skeletal disorders; Infection - Studies of infection and infectious agents; Anaesthesiology - Pain management

• Registration Number: ACTRN12615000958583
• Lead Sponsor: Monash University

Brief Summary

A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-09-11
• Study Completion: 2022-07-26
• Last Update Posted: 23 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 170

Inclusion Criteria

1 Chronic low back pain (Chronic > 3 months in duration; pain in the region bordered above by the 12th ribs and below by the gluteal folds)
2. Aged 18-60 years
3. Presence of a lumbar disc herniation on MRI

Exclusion Criteria

Specific pathological entities, such as metastasis and osteoporosis; any contra-indication or allergy to antibiotics; antibiotic therapy in the past 3 months; immuno-compromised; osteomyelitis; current pregnancy or lactation; any liver or kidney disease; candidate for spinal surgery; major co-existing illness which may confound assessment of function; inability to provide consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain Intensity will be assessed with the Low Back Pain Rating Scale and Visual Analogue Scale. [- Baseline and 90 days (which is at the start and end of the intervention period)<br>- 6, 9 and 12 months after commencement of the intervention.];Disability<br>Roland Morris Disability Questionnaire[- Baseline and 90 days (which is at the start and end of the intervention period)<br>- 6, 9 and 12 months after commencement of the intervention.];Absence from paid/unpaid work<br>Short Form Health and Labour Questionnaire [- Baseline and 90 days (which is at the start and end of the intervention period)<br>- 6, 9 and 12 months after commencement of the intervention.]